Ximeclav
Cefuroxime Axetil + Clavulanic Acid
Presentation
- Ximeclav 250 tablet: Each film-coated tablet contains Cefuroxime 250 mg as Cefuroxime Axetil USP and Clavulanic Acid 62.5 mg as Clavulanate Potassium BP.
- Ximeclav 500 tablet: Each film-coated tablet contains Cefuroxime 500 mg as Cefuroxime Axetil USP and Clavulanic Acid 125 mg as Clavulanate Potassium BP.
- Ximeclav Powder for Suspension: Each 5 ml reconstituted suspension contains Cefuroxime 125 mg as Cefuroxime Axetil USP and Clavulanic Acid 31.25 mg as Clavulanate Potassium BP.
Descriptions
Cefuroxime is a second-generation, beta-lactam, bactericidal, cephalosporin antibiotic. Cefuroxime is active against a wide range of Gram (+) ve and Gram (-) ve susceptible bacteria. Clavulanic acid is structurally similar to beta-lactam antibiotics & exhibits negligible antibacterial activity. Clavulanic acid acts as a β-lactamase inhibitor by binding irreversibly to β-lactamase enzymes.
The presence of clavulanic acid in Ximeclav formulation protects the effectiveness of Cefuroxime from degradation by beta-lactamase enzymes and effectively extends the antibacterial spectrum of Cefuroxime to many bacteria normally resistant to Cefuroxime and other cephalosporins.
Indications: Ximeclav is indicated for –
- Pharyngitis/Tonsillitis
- Acute Bacterial Otitis Media
- Acute Bacterial Maxillary Sinusitis
- Acute Bacterial Exacerbations of Chronic Bronchitis and Secondary Bacterial Infections of Acute Bronchitis
- Uncomplicated Skin and Skin-Structure Infections.
- Uncomplicated Urinary Tract Infections
Therapeutic Class
Antibiotic, 2nd generation Cephalosporin with Clavulanic Acid