Presentation

Trigger 50 tablet: Each tablet contains Sildenafil Citrate INN 70.24 mg equivalent to Sildenafil 50 mg.

Description

Sildenafil is a selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). When sexual stimulation causes the local release of nitric oxide; inhibition of PDE5 by Sildenafil produces increased levels of cGMP in the corpus cavernosum. This results in smooth muscle relaxation and inflow of blood into the penile tissues, thereby producing an erection. Sildenafil has no effect in the absence of sexual stimulation. Sildenafil is indicated for the treatment of erectile dysfunction and pulmonary arterial hypertension.

Therapeutic Class

Antihypertensive