Premesis
Ondansetron
Presentation
Premesis 4 Tab: Each film-coated tablet contains OndansetronHClDihydrate BP equivalent to Ondansetron 4 mg.
Premesis 8 Tab: Each film-coated tablet contains OndansetronHClDihydrate BP equivalent to Ondansetron 8 mg.
Premesis Oral Sol.: Each 5 ml contains Ondansetron Hydrochloride Dihydrate BP equivalent to Ondansetron 4 mg.
Premesis Inj.: Each ampoule of 4 ml contains Ondansetron Hydrochloride Dihydrate BP 2.49 mg equivalent to Ondansetron 2 mg.
Description
Premesis (Ondansetron) is a selective 5-HT3 receptor antagonist. While its mechanism of action has not been fully characterized, Ondansetron is not a dopamine-receptor antagonist. Serotonin receptors of the 5-HT3 type are present both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema. It is not certain whether Ondansetron’s antiemetic action is mediated centrally, peripherally, or in both sites. However, cytotoxic chemotherapy appears to be associated with the release of serotonin from the enterochromaffin cells of the small intestine.
Therapeutic Class: Antiemetic
